The campaign will take place this year from 8-14 February, and aims to help give orphaned and abandoned children a family.
Members of the public can choose to sponsor a child for £20 a month, or can apply for a fundraising pack by registering online.
The charity currently cares directly for more than 78,000 orphaned and abandoned children in 500 Children's Villages, in 124 countries around the world.
The charity's goal during World Orphan Week is to give 1,000 more orphaned and abandoned children a mother, a home, and a family for life.
SOS Children's main partner for WOW 2010 is the Monsoon Accessorize Trust. Monsoon has created a children's T-shirt from which 100 per cent of the profits will go to SOS Children.
Celebrity supporters including Chronicles of Narnia actress Georgie Henley, TV presenters Phil Spencer and Louise Minchin, and Tottenham Hotspur FC.