The corporate partnership will see the charity and the social networking site launch a series of events next year, focusing on their joint aims to reunite and find people.
Users of Friends Reunited, Genes Reunited and Friends Reunited Dating will be asked to support Missing People by donating money and getting involved in searches.
Missing People's PR officer Jessica Cotton said this would help extend the charity's reach and be a welcome boost to its fundraising events.
'We are looking to roll out more of an events calendar next year to broaden our appeal. We want as many people as possible to join the search and keep it alive,' she said.
She added: 'Missing People is well known, but there is a perception that we are a government-funded agency. But we're actually a charity.'