The agency was awarded the account following a four-way pitch. Cube replaces two-year incumbent Seal Communications.
The six-figure campaign aims to build consumer awareness and understanding of the South African wine industry and its focus on sustainable winemaking.
The agency will target consumer press and broadcast media as part of the brief.
Cube PR director Scott Burton will report into Wines of South Africa UK market manager Jo Mason.
'It is difficult for wine producers to get wine outside of the wine pages in the press and that is our aim as part of the activity,' said Burton.