Noble expects to leave H&K later this month before starting at Edelman in early November as head of BioScience International, its medical comms offering.
At Edelman he will be reunited with UK health MD Mike Kan, who is ex-H&K. The duo briefly worked together at H&K, with Kan joining Edelman in October last year.
Noble will report to Kan and New York-based BioScience global managing director Mark Deitch.
Noble has been at H&K, where he reports to EMEA head of healthcare Nick May, for just under two years. Before joining the agency, he was commercial director at PPD, a clinical research organisation.
At H&K, Noble is managing director of its seven-strong Medical Knowledge Group (the agency's med comms unit) as well as its Healthcare Strategic Consulting offering.
BioScience has around 60 employees: 40 in New York, 15 in London, and a brace of staff in Paris and Frankfurt.
Kan and Noble want to recruit a BioScience director upon the latter's arrival at Edelman. The recruitment drive is partly explained by long-serving BioScience London director Jasmine Zidane's recent relocationto Australia. She is still working for Edelman in its Sydney office, said Kan.
In addition, BioScience director Neil McCallum-Deighton has just left (PRWeek, 22 September). It has also emerged that account director Dr Andrew Fitton left BioScience around three months after joining late last year.
Other senior BioScience London staff include Nicola Goldsmith, Laura McKeever, Sarah Jackson and Elinor Washbrook.