Wilson, 58, will leave the firm, where he worked for four years, once a replacement is found.
He joined Dell in 2002 from rival manufacturer Hewlett-Packard, where he was EMEA director of brand and company communications. Before joining H-P back in 1984, he held other senior marketing and communications roles at Rank Xerox International and Singer.
Shortly before Wilson's arrival, Dell hired GCI to its UK PR account.
His departure comes as Dell pushes through a cost-cutting plan across the Texas-based group, which is hoping to rebuild sales in the UK and Europe.
Dell said last November that third-quarter group profits had fallen 30 per cent after corporate and government spending on IT slowed, particularly in the UK.
The group now has plans to cut 230 jobs at its UK headquarters in Bracknell, Berkshire.
However, Dell's laptop, computer storage product and customer services sales in Europe were up 18 per cent in the fourth quarter of last year to £2.1bn. Sales in the US grew ten per cent.
While Dell has a 30 per cent share of the US PC market, the company hopes it can expand its ten per cent share in Asia and Europe.
Last year Dell opened a sales and technical support centre in Glasgow employing more than 300 people. It plans to expand this to 850 staff by 2008 and will open a manufacturing plant in eastern
Europe this year.