Regeneration company Meridian Delta Ltd (MDL) has hired the agency to promote one of London's biggest-ever redevelopments following a five-way competitive pitch.
Four head of media relations Greg Moore said: 'The Greenwich Peninsula is mirroring what has happened in Canary Wharf.
'Our brief is to help sign up property developers, attract retailers and position it as a good place to live and work.'
The 20-year programme involves creating 10,000 homes, schools, medical facilities, transport systems and parkland, as well as 340,000 square metres of commercial space and 33,000 square metres of retail space.
MDL - a joint venture between Quintain Estates and Development and Lend Lease - had retained The London Communications Agency for four years before reviewing the account.