The campaign, being promoted by Red Door Communications, will flag up how bleeding disorders affect many women, although they are traditionally associated with men.
It represents one of the most substantially funded specific awareness campaigns backed by the society in recent years.
Von Willebrand's disease is generally a hereditary condition and affects around one in 100 women in the UK. It inhibits normal clotting processes, leading to excessive or prolonged bleeding. It is often discovered after surgery or a major accident.
The campaign will highlight treatments - although there is no known cure.
Red Door will target consumer media, agony aunts and female 'role models who appeal to girls and women across a range of ages and life stages'.
It won a three-way pitch, with agency director Julia Harries leading a four-strong account team.
Red Door worked with the Haemophilia Society on a project last year, promoting its Annual Sports Award for Children.