The DoH has teamed up with charity Cancer Research UK to run the campaign.
It follows the skin cancer SunSmart drive jointly promoted by the two bodies for the past three years.
Cases of mouth cancer have risen by 22 per cent since 1995 - around 4,400 people are diagnosed every year and nearly 1,600 die from the disease.
The figures have been blamed on drinking and smoking trends.
The campaign starts during Mouth Cancer Awareness Week (13-19 November).
After a general awareness drive, the focus will be on 'at-risk' groups, such as the over-40s, south Asians who chew tobacco, and smokers and drinkers.
Local and national newspapers, morning TV news programmes, fitness press, lads' mags and lifestyle titles will be approached.
Cancer Research head of health information Sara Hiom said early detection saved lives.