Nottingham kick-started the Big Spring Clean campaign last week, with staff abandoning their street-cleaning duties for a day.
The 24-hour period without street cleaners was designed to encourage the public to use bins by showing how much rubbish is dropped every day.
The Big Spring Clean will run until July, urging the public to not drop litter or fly-tip. Enforcement has been stepped up and businesses have been called upon for support.
A council spokesman said: 'There were problem litter areas that grabbed the attention of the media and the public when we stopped cleaning for a day. Now neighbourhood wardens will target areas and hand out on-the-spot fines.'
During the first week of the drive, wardens handed out pouches, which people can carry around to dispose of cigarette butts and chewing gum.
Fast-food outlets and other businesses are being asked to sign a pledge to keep the area around their premises clean.
The campaign is part of the Respect for Nottingham initiative.