Best-selling writers Anne Fine and Jacqueline Wilson will front the campaign with TV, radio and press interviews in the run-up to the January event.
The charity has produced free resource packs for schools to help teachers plan activities during the week, aimed at building awareness and breaking down taboos associated with cancer.
Activities suggested include designing a poster, writing a play and hosting a school assembly.
Macmillan is also hoping to make a big splash by incorporating kids’ fundraising event the Big Hush, a sponsored ten-minute silence, into the programme.
In previous years, more than 6,000 schools have participated in Cancertalk Week. Macmillan press officer Nicola Ryan said the media campaign will be targeted at a range of broadcast and press outlets.
‘Because Cancertalk is such a vast subject, touching on health, children, medical and social issues, we will be targeting a broad spectrum of media,’ she said.
Press ads for the school resource packs have appeared in several broadsheets.
One in three people in the UK is affected by cancer and many children are affected by the disease, according to the charity.