Grande said issues connected with brand marketing and careers would take centre stage as topics to be covered in the section from now on.
He takes over next week from Andy Davis, who has moved to be editor of the paper's Inside Track section.
Published every Tuesday, Creative Business covers the use of media, marketing, advertising, PR and technology within companies.
Grande said he hoped coverage of career development in the supplement's key sectors of media, marketing and technology would be boosted following his appointment.
'We will have genuine interest in careers advice within these sectors as part of a long-running series. We are trying to give readers a bit more value-added copy, so it will be about developing talent within the service sector, ' he said.
'Our strongest suits so far have been media and advertising trends. We could probably do more marketing, both direct and on brands.'
'The FT's core readership is decision-makers from board level right down to fairly junior level. We are obviously interested in these groups, but equally in people who are being innovative, or who can argue the case for or against something.'
The section also hopes to focus on the way technology platforms work within business, he said, but stressed that no major shift in content was likely before next month.
Grande will be talking to agencies in the areas covered by Creative Business, and studying new reader research on the supplement. 'Based on that, there might be more significant changes,' he hinted.
Grande was formerly the paper's media correspondent, and has worked at the FT for four years.
Deputy editor Emiko Terazono will remain in that role, the paper announced.
Stephanie Kirchgaessnertakes over part of Grande's role, writing about print media for the main paper.