It is understood the campaign will begin by summer and will target the young over the dangers of Class A drugs, in particular heroin.
A key message will be promotion of the Government's national drugs helpline.
Fishburn Hedges director Victoria Tate said the first phase of the work is to liaise with stakeholders, such as the charity Centrepoint, as well as local health workers to give them advance notice of the campaign.
This liaison work is set to last for two months before a major media relations push, to coincide with a print and TV advertising campaign being handled by Mother.
The campaign is co-ordinated by the DoH and the Home Office, with Fishburn Hedges reporting to DoH behavioural change marketing comms team leader David Horton.