Ryan joined the internet streaming service in the Amsterdam-based position in early 2017. Before that she was head of external communications, Europe, at Vodafone, based in London and Brussels.
In a post on Linkedin, Ryan said: "After an exhilarating two years at Netflix, it is time for a new adventure. Delighted to confirm I'm joining Naspers, one of the largest technology investors in the world, in a newly created international communications leadership role based in Amsterdam.
"With Naspers this week announcing its intention to list its international internet assets on Euronext Amsterdam - which would create the largest listed consumer internet group in Europe by asset value - and operations and investments across the world in markets including China, India, Russia, Brazil and South Africa, it’s going to be an exciting role."
Naspers is currently listed on the London Stock Exchange and the Johannesburg Stock Exchange.
Earlier in her career, Ryan held roles at PR agencies Powerscourt in London and Drury Porter Novelli in Dublin.
Ryan’s departure follows changes in Netfllix’s senior comms team in recent months.
The company hired Rachel Whetston from Facebook at chief communications officer in August 2018.
The following month, Jonathan Bennett joined as UK and Ireland corporate comms director after 10 years at Discovery Communications. Soon after that, former Twitter UK communications manager Sam Hodges joined as director of content communications - a new, London-based role reporting to Netflix’s EMEA headquarters in the Dutch capital.
Earlier this year, Tamsyn Zietsman took the role of UK and Ireland publicity director - she was formerly head of PR at the Jamie Oliver Group.
Bennett told PRWeek Netflix is currently looking to fill the EMEA corporate comms director role.