The EHRC will work with up to 30 refugees and asylum seekers in Wales to create a series of short films and case studies that will be shared across social media and on its website next spring.
A celebratory launch event is also expected to kick off the comms activity in March 2018.
The target audiences for the project include the general public, national and local public bodies, government departments and third sector organisations.
"Our communications work in Wales tells us that in order to overcome prejudice, traditional myth-busting does not work," a spokesperson for EHRC told PRWeek.
"Communications research shows that audiences are more receptive to unfamiliar opinions when they are framed within the context of shared values.
"When it comes to human rights, these values are equality, justice and fairness. There is a need for the lived experience of refugee and asylum seekers to be central to the debate in Wales."
The EHRC is celebrating its 10th anniversary since it was established by the Equality Act in October 2007, and has run a series of comms campaigns in recent years, including work with Premiership Rugby and the England and Wales Cricket Board to make sport more inclusive, as well as its project on race inequality.
Within this anti-prejudice project, the films and case studies will span a wide range of experiences of asylum seekers and refugees in the country, covering people living in different parts of Wales, both rural and urban; people with disabilities, from LGBT groups and a variety of age demographics.
The work to document the stories of a diverse range of people will be carried out by an agency, and the programme includes film-making, as well as project and event management.
Creating the films and case studies, plus other shareable resources, is expected to take place between November and March.
"[There is a] need to consider how to sensitively engage with a wide range of people who have refugee status or are going through the asylum process and be mindful of any activities that might impact the individuals in their application for asylum," added the EHRC spokesperson.
Once an agency is appointed to carry out the project, the EHRC expects to develop a timeline for the campaign roll-out.