Fifty per cent of its business is now conducted overseas, and work undertaken includes medical education and lobbying policy-makers.
The three new companies within the group are Olog-e, a digital communications firm; Fast4wD, aimed at recruiting patients for clinical trials; and an as-yet-unnamed third company aimed at marketing brands to patients within existing regulatory constraints.
The trio of new firms sit within the group alongside existing companies, which have also rebranded.
Shire Hall Communications becomes Shire Health London, Shire Hall New York becomes Shire Health New York and Shire Hall International also substitutes 'Hall' for 'Health'.
4D Communications remains as it was within the group.
Shire Health CEO Gloria Gibbons said the rebrand, which occurred too late to be incorporated into this week's PRWeek Top 150 agency rankings, was aimed at making the agency's core work more obvious to potential and existing clients: 'Our new name clearly states where our expertise lies.'
Gibbons added that the launch of the three new companies was an effort to take the lead in new areas in healthcare communications.