The move follows Golley Slater's decision last year to sell its Scottish business to PR firm Clark Communications, which was set up in 2012 by former Weber Shandwick vice president Lesley Brydon.
Eileen Stretton, managing director of the Leeds office, who was appointed in 2013 to rebuild Golley Slater's business in the north of England, will step down in the coming weeks following a handover period, PRWeek understands.
Though her next move is unclear, Stretton said: "I am still currently working with the board for a while to transition the majority of the contracts we have here to the London team."
She added: "Moving forward, Golley Slater is taking the PR operation away from structural bases in the regions, to a more flexible model."
Four people worked at the Leeds office. Stretton confirmed the agency would continue to provide PR support to clients in the north of England on an ad-hoc basis.
Golley Slater, which was named by PRWeek in 2016 as the UK's 11th largest agency outside London, closed its Birmingham office in 2013.
Martin Long, group MD at Golley Slater, told PRWeek the agency has had to evolve in recent years to match the "needs" of its clients.
"We now offer an affiliate support service to our clients throughout the UK, which can be dialled up or down dependent on their needs," Long said.
Long also confirmed no staff were made redundant because of the closure of the Leeds office.
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