The Coming Home for Christmas campaign, created by ad agency Havas, follows two elderly teddy bears as they make their way toward the arrivals gate - a point at which they 'transform' into the grandparents of two expectant children.
Heathrow Airport head of PR communications Julia Weir told PRWeek that the video represents "that 'Love Actually' moment" people experience when coming home - particularly at Christmas.
According to Weir, the campaign is being shared across social media and in paid spots in cinemas.
The video follows the airport's First Flight campaign, which launched earlier this year. Both are part of an ongoing brand campaign that marks Heathrow's 70th anniversary.
Heathrow is the UK's busiest airport, welcoming more than 70 million passengers each year.
Late last month, the Government announced plans to back the development of a third runway at Heathrow, following a lengthy PR battle against rival hub Gatwick.