The airline said he would lead Ryanair’s public affairs engagements with EU institutions and European governments.
Samoilovich’s most recent role was senior manager public policy, Europe, at Uber.
He has a background in aviation, with previous roles at Airbus and Boeing. Samoilovich also chaired aviation trade body ADS.
Ryanair chief legal and regulatory officer Juliusz Komorek said: "His extensive experience and knowledge will be a key asset to Ryanair, as we continue to work with the EU to increase the competitiveness of the European air transport industry, to the benefit of consumers."
Samoilovich said: "I look forward to working closely with the EU and European governments to deliver even more choice and low fares to consumers."