The speech is part of Ogilvy & Mather's Inspire seminar series.
Lewinsky describes herself as one of the first victims of cyber-bullying following the online harassment she suffered following her affair with Clinton 17 years ago when she was 24 years old.
Lewinsky has recently made two high-profile media appearances at the TED conference and Forbes, where she spoke candidly about how online victimisation can lead to suicidal thoughts and how advertisers need to take responsibility for the role they are playing in creating future pop culture.
Speaking at Cannes, Lewinsky will ask the industry some challenging and uncomfortable questions about the emerging social media environment that it has had a hand in shaping.
Tham Khai Meng, worldwide chief creative officer at Ogilvy & Mather, said: "Monica Lewinsky is an eloquent, courageous and highly intelligent woman as evidenced by her recent TED Talk 'The Price of Shame', which has had more than five million views to date.
"As the living embodiment of what can happen when a human being is dehumanised online by virtual stone throwers, she moves the important topic of cyber-bullying centre stage. We are proud to support Monica in her mission to stamp out online harassment. We believe businesses like ours can play an important role in getting her inspiring messages out to create a more compassionate, empathetic society."
Lewinsky added: "Public shaming as a blood sport has to stop, and it's time for an intervention on the internet and in our culture."
The speech will take place at the Cannes Lions International Festival of Creativity on Thursday 25 June at 2pm.
For the first time, this year Cannes is introducing the 'Glass Lion' award – given for work that celebrates gender equality.