The company claims it could be the "first" PR agency to use the currency, which has seen rapid fluctuation in recent months.
Technology account manager Jonathan Saatchi said the agency wanted to spread the use of Bitcoin among clients too.
"Bitcoin is one of the most talked about currencies," he said, "and we want to be pioneers in encouraging its use among the many young technology companies based in the North West of the country."
Bitcoin allows users to send and receive the finance via software on personal computers, mobile devices or web applications, bypassing central authorities and banks.
However, after a meteoric rise from a trading value of $13.50 at the start of 2013 to $1,240 in December, it suffered a hit after China moved to restrict trade of the currency.
Saatchi added: "MC2 recognises that the Bitcoin exchange rate can fluctuate rapidly and because of this we will consider business proposals and payment on an individual basis."
MC2 was established in 1999, and has worked with clients including Cadbury, Deloitte and Red Bull.