Zeebox launched in the UK in October as a second-screen app that turns TV into a two-way, social viewing experience.
The apps for the iPad, tablets and laptops allow users to see what their friends are watching and share, chat and tweet about TV programmes.
The deal will see the pair creating new content to accompany Channel 4 programme Desperate Scousewives, which starts on 28 November.
Zeebox users will be provided with tailored interactive content from Channel 4 alongside the standard service features, such as related Twitter feeds, news, instant chat and information from Wikipedia.
The Desperate Scousewives content will include a bespoke Twitter visualisation app, cast tweets, cast videos, music information through iTunes, as well as links to a Scouse glossary and a Google map plotted with key Liverpool locations.
Jodie Morris, senior producer for entertainment, Channel 4 Online, said that the deal would help enhance the TV experience for its viewers by 'creating and curating online buzz around the show.'
Zeebox creator Rose is the former chief technology officer of the BBC's iPlayer.