The Google-owned website is reported to be investing about $100m (£62.3m) in the venture. The new channels will contain videos from celebrities including Madonna and Ashton Kutcher, and publishers such as The Wall Street Journal.
Vice, Red Bull, The Onion and Reuters are among the first partners, while rappers Jay-Z and Pharrell Williams are also expected to roll out content channels. The first will launch next month.
Robert Kyncl, global head of content partnerships at YouTube, wrote in a blog post: 'Our goal with this channels expansion ... is to bring an even broader range of entertainment to YouTube, giving you more reasons to keep coming back again and again. For advertisers, these channels will represent a new way to engage and reach their global consumers.'