The £6million campaign, backed by major health charities, shows the damage that is being done to drinkers' organs while they are drinking in a pub or at home.
It is being launched by Public Health Minister Gillian Merron today and is part of the cross-Government strategy to tackle the harms that alcohol causes.
The DH has developed the campaign in association with Cancer Research UK, the British Heart Foundation and the Stroke Association to create the series of stark TV, press and outdoor adverts showing the harm that regularly drinking more than two drinks a day can cause.
A new YouGov poll launched to coincide with the campaign shows that more than half (55 per cent) of English drinkers misguidedly believe that alcohol only damages your health if you regularly get drunk or binge drink.
The survey of over 2,000 adults also found that 83 per cent of those who regularly drink more than the NHS recommended limits of two to three units a day for women (about two small glasses of wine) and three to four units a day for men (about two pints of lager) don't think their drinking is putting their long-term health at risk.
With 10 million adults in England estimated to be drinking above the recommended limits, this is equivalent to around 8.3 million people potentially unaware of the damage their drinking could be causing.
The campaign website, www.nhs.uk/drinking launches on Monday 1 February and will feature interactive tools to arm people with the information they need to make healthier choices.
The campaign will also include an 8.5million door drop across the UK in areas with higher risks of drinkers.