The office is designed to help the firm better serve its clients that are based, or have a substantial presence, in the North.
Capital MS&L wants to make the most of bourgeoning local economies, particularly Manchester's.
‘We see a strong need in the North in general for financial comms and investor relations consultancy,' said Capital MS&L managing director Steffan Williams.
He added: ‘This is particularly notable given the flourishing financial and professional services communities.'
The office, located in the city's Deansgate quarter, will be headed by Capital MS&L director Peter Curtain. He will divide his time between Manchester and London.
Curtain, who has worked in City PR for six years, was previously business editor of The Yorkshire Post and City editor of Business AM.
‘The growing list of Northern-based public companies is a testament to the region's economic strength, the vitality of its entrepreneurs and the ability of its financial and legal advisers,' he added.