Hopscotch will design a series of workshops to launch in the summer term, aiming to support students around exam time.
The agency will work with personal, social and health education (PSHE) and behaviour change experts to put the course together.
More than 100 schools will be involved in the workshops initially. The programme is being offered to schools whose students are taking part in work experience placements at Nuffield Centres across the UK, but it is planned to be rolled out more widely in the future.
Hopscotch director Sam Mercer said: "The majority of information and teaching resources for teens focus on a specific area e.g. fitness, mental health or sexual health. This programme will be one of the few to take a 360-degree mind and body fitness approach, acting as a gateway to stimulate debate, interest and further exploration of the cornerstones of wellbeing during these often turbulent teen years."
Nick Green, head of healthy start programmes at Nuffield Health, added: "Hopscotch’s experience in creating meaningful education and community engagement programmes for teenagers means the agency is an ideal partner for our work to improve the health of the nation."