Argos, Homebase, Marks & Spencer and Lloyds Banking Group announced they are joining the Dementia Friends scheme, an initiative started by the charity to help staff learn about dementia.
The commitments follow a drive by the charity to capitalise on links with businesses forged at the G8 summit on dementia in December last year.
Health Secretary Jeremy Hunt, who led the summit, last week pledged £90m of government funds for dementia research.
Alzheimer’s Society director of external affairs Alison Cook said the campaign was audience specific and the charity was actively seeking further partnerships.
"We’re targeting businesses that may come into contact with people with dementia, and we want to design something specific to them in terms of their employees," she said.
She added the charity had a team in place to specifically work on relations with businesses.
Speaking to PRWeek, Chris Wermann, director of corporate affairs at Argos and Homebase parent company Home Retail Group said that the partnership would allow a holistic mix of activities to help the community, such as fundraising activities and staff training.
"With corporate responsibility we want to do something where we can make a difference to the community, but also it needs to be something that’s going to be relevant and meaningful to our employees," he said.