The Liberal Democrats' head of comms Tim Snowball is taking a new role as director of political operations and general election planning manager.
Gilpin-Jacobs will be based in Clegg's office and will head up the Lib Dems' comms team in government.
Gilpin-Jacobs said: "This is a really interesting move for me, as I am able to bring to a political role my years of commercial and media-focused experience – over what will be a fascinating period in UK politics."
Her appointment comes four months after she left her role as global comms director for the Financial Times Group, where she had worked since 2006.
She was responsible for developing, managing and delivering the FT’s global commercial strategy, with specific oversight of external, corporate, brand and internal comms.
PRWeek profiled her in 2008 and her CV includes several years as a journalist before she entered the world of comms:
2006 Global comms director, FT
2000 International comms director, Time magazine
1999 Head of corporate, Freud Communications
1997 Account director, The Hubbell Group, Boston
1996 Assignment editor, CNBC/Financial Times Television
1994 Launch editor, The Investor magazine
1992 Reporter and editor, Breaking The Mould magazine