Jones, who joined the charity as a consultant in January 2011 before being promoted last November, will now be senior account director at the agency.
Her remit is to build the skills and reputation of Amaze PR, which sits within the digital marketing and technology company Amaze.
She will be working on the agency’s recent Manchester City Football Club win and will be involved with both promoting the agency and overseeing new business.
Jones said the move to the Manchester-based agency was partly prompted by the decision to move north with her partner.
She added: ‘I loved working at Save the Children. It was incredibly rewarding and I was really sad to leave, but it was a life choice to make this move and fortunately I was offered a great role. Manchester has a real buzz about it and I’m thrilled to join Amaze at such an exciting time.
‘It's a major player nationally and now internationally, and the PR team, with its experience of creating and managing content and conversations, sits right at the heart of the business.’
Jones will work with Sandra McDowell, who heads up Amaze PR,on new business and will seek opportunities to integrate the PR division into the wider Amaze business. She will also sit across the wider Amaze Group senior leadership team.
Before her time at the charity, Jones worked at Sky Arts, Sky Movies, and Channel 4.
Ishbel Matheson, director of media at Save the Children, said: 'Being head of PR at Save the Children is a challenging yet incredibly satisfying role. We've been fortunate enough to have had some amazing people - such as Sam Jones - who have helped us one of the leading international aid agencies, in terms of PR profile, in our sector.
She added: 'Sam is a hard act to follow. But we have a great team, and we're looking for someone who has an great track record delivering high-impact influential PR, and with loads of ambition and creativity. Most important of all, we're looking for a PR professional who wants to use their skills and ability to help us make the world a better place for children.’