The party declined to comment on Macrory’s next steps.
Formerly Daily Star political editor, Macrory has worked for the party for many years. He was drafted into Downing Street to help with media handling, but last year headed back to Conservative HQ to take the deputy political director role.
It has been reported that several people approached about the coming vacancy have declined.
Meanwhile, No 10 sources have dismissed reports that Steve Field, David Cameron's civil service press chief, is about to quit.