Ian Cotton will leave on 13 May, which comes after media scrutiny of his role in issues such as the Luis Suarez racial abuse story.
The club’s comms team was criticised for its handling of the Suarez affair last October, in which the striker was charged for racially abusing Manchester United’s Patrice Evra.
Cotton has also been singled out for not taking more control of manager Kenny Dalglish, with the media complaining about the ex-Liverpool player’s treatment of journalists at press conferences.
Former Liverpool striker and TalkSport host Stan Collymore has questioned Cotton’s role, saying he is responsible for ‘presenting a negative image of the club to millions of Liverpool fans around the world’.
The Fenway Sports Group and Liverpool FC confirmed Cotton’s departure via a statement on the club’s official website.
LFC managing director Ian Ayre said: ‘We would like to thank Ian for the important contribution he has made to the club during his long career here.
‘He has played a key role as a member of the executive team in managing our relationships with key external stakeholders in the media and in the community. We wish Ian every success in his future career.’
The club also stated that ‘further communication regarding the comms and community departments would be announced in due course’.
Cotton said: ‘It has been a privilege to be at Liverpool for the past 16 years. I would like to thank everyone I have worked with for all their support during that time and wish this great club all the best for the future.’