The agency will look to give the car giant a presence at events such as London's Fashion Week to build on the brand's high-end, luxury reputation.
Peter Cross, managing partner for Yellow Door, commented: 'We're talking about how a brand can go beyond consumers and be impactful and engaging. We will look to really give the consumer and Mercedes-Benz shopper an insight into the world of fashion. We don't think it has been done before.'
Yellow Door has been charged with solidifying Mercedes-Benz' position as a global luxury car brand through its association with fashion.
Cross added: 'So much has changed – how we shop, celebrity endorsement – and what's interesting is how these two worlds can meet.'
Mercedes-Benz celebrates its 125th birthday this year.
Yellow Door also looks after luxury brands Louis Vuitton and Swarovski.